The development of the pathological process is accompanied by viraemia, which lasts 10 -14 days, with a predominance of toxic and toxic-allergic reactions in the internal organs, especially the cardiovascular and nervous systems.
The main link in the pathogenesis of a vascular lesion, showing increased permeability and fragility of the vascular wall, a violation of micro circulation. These changes are manifested in patients with the appearance of rinoragy (nasal bleeding), hemorrhages on the skin and mucous membranes, bleeding in internal organs and lead to the development of pathological changes in the lung: edema of the lung tissue with multiple hemorrhages in the alveoli and interstitium.
The fall of vascular tone leads to venous congestion of skin and mucous membranes, congestive hyperemia of internal organs, disturbance of microcirculation, diapedesic hemorrhage at a later date – thrombosis of veins and capillaries.
These vascular changes also cause hyper secretion of CSF with the development of circulatory disorders, leading to intracranial hypertension and brain edema Clinic.
The main symptoms coincide with the usual symptoms of influenza – headache, fever, cough, vomiting, diarrhea, runny nose. An important role in pathogenesis played by the defeat of lungs and bronchi due to increased expression of several factors – mediators of inflammation (TLR-3, γ-IFN, TNFα, etc.), resulting in multiple injuries of the alveoli, necrosis and hemorrhage The high virulence and pathogenicity of this strain may be due to the ability to non-structural protein NS1 (inherent in the virus) to inhibit the production of interferon type I infected cells . The defective gene for this virus are significantly less pathogenic.
Diagnosis
The clinical course of the disease in general coincides with the course of the disease when infected with other strains of influenza virus. A reliable diagnosis is established when sertotipirovanii virus
Prevention
In view of the primary specific prophylaxis (primarily those categories of risk) in Russia and abroad will be accelerated development and registration of specific vaccines on the basis of the selected strains. Epidemiologists also welcome the vaccination of “seasonal” influenza, containing antibodies against the damaging agents (proteins) of three different from the “pork” strain of the virus.
In the memo about the high pathogenic flu, WHO identified the need to eliminate close contact with people who “seem to be unhealthy, with a high body temperature and a cough. We recommend thoroughly and frequently wash hands with soap and water. “Stick to a healthy lifestyle, including full sleep, consumption of healthy food, physical activity” [12]. With proper heat treatment will kill the virus. Primary non-specific prevention aims at preventing the virus in the body, and on enhancing non-specific immune response to prevent development of disease.
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